Minireview: Mitochondrial energetics and insulin resistance

被引：56

作者：

Civitarese, Anthony E. ^{[1
]}

Ravussin, Eric ^{[1
]}

机构：

[1] Pennington Biomed Res Ctr, Skeletal Muscle Metab Lab, Baton Rouge, LA 70808 USA

来源：

ENDOCRINOLOGY | 2008年 / 149卷 / 03期

关键词：

D O I：

10.1210/en.2007-1444

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity, insulin resistance, type 2 diabetes mellitus, and aging are associated with impaired skeletal muscle oxidation capacity, reduced mitochondrial content, and lower rates of oxidative phosphorylation. Several studies have reported ultrastructural abnormalities in mitochondrial morphology and reductions in mitochondrial mass in insulin-resistant individuals. From lower organisms to rodents, mitochondrial membrane structure, function, and programmed cell death are regulated in part by the balance between the opposing forces of mitochondrial fusion and fission, suggesting they may also play an important role in human physiology.

引用

页码：950 / 954

页数：5

共 57 条

[11] Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat [J].

Goodpaster, BH ;

Thaete, FL ;

Simoneau, JA ;

Kelley, DE .

DIABETES, 1997, 46 (10) :1579-1585

[12] Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk [J].

Handschin, Christoph ;

Choi, Cheol Soo ;

Chin, Sherry ;

Kim, Sheene ;

Kawamori, Dan ;

Kurpad, Amarnath J. ;

Neubauer, Nicole ;

Hu, Jiang ;

Mootha, Vamsi K. ;

Kim, Young-Bum ;

Kulkarni, Rohit N. ;

Shulman, Gerald I. ;

Spiegelman, Bruce M. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (11) :3463-3474

[13] Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA [J].

Herlan, M ;

Vogel, F ;

Bornhövd, C ;

Neupert, W ;

Reichert, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (30) :27781-27788

[14]

Hollenbeck PJ, 2005, J CELL SCI, V118, P5411, DOI [10.1242/jcs.02745, 10.1242/jcs.053850]

[15] Fuel selection in human skeletal muscle in insulin resistance - A reexamination [J].

Kelley, DE ;

Mandarino, LJ .

DIABETES, 2000, 49 (05) :677-683

[16]

Kelley DE, 1999, AM J PHYSIOL-ENDOC M, V277, pE1130

[17] Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes [J].

Kelley, DE ;

He, J ;

Menshikova, EV ;

Ritov, VB .

DIABETES, 2002, 51 (10) :2944-2950

[18] Mitochondrial GTP regulates glucose-stimulated insulin secretion [J].

Kibbey, Richard G. ;

Pongratz, Rebecca L. ;

Romanelli, Anthony J. ;

Wollheim, Claes B. ;

Cline, Gary W. ;

Shulman, Gerald I. .

CELL METABOLISM, 2007, 5 (04) :253-264

[19] MITOCHONDRIAL RETICULUM IN LIMB SKELETAL-MUSCLE [J].

KIRKWOOD, SP ;

MUNN, EA ;

BROOKS, GA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (03) :C395-C402

[20] Peroxisome proliferator-activated receptor-γ co-activator 1α-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency [J].

Koves, TR ;

Li, P ;

An, J ;

Akimoto, T ;

Slentz, D ;

Ilkayeva, O ;

Dohm, GL ;

Yan, Z ;

Newgard, CB ;

Muoio, DM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (39) :33588-33598

← 1 2 3 4 5 6 →