Xenon-129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

被引：55

作者：

Duhamel, G

Choquet, P

Grillon, E

Lamalle, L

Leviel, JL

Ziegler, A

Constantinesco, A

机构：

[1] Univ Grenoble 1, INSERM, Lab Mixte, CEA,U438,Lab Rech Correspondant, Grenoble, France

[2] Univ Strasbourg, CHU Hautepierre, Lab Biomecan, Strasbourg, France

来源：

MAGNETIC RESONANCE IN MEDICINE | 2001年 / 46卷 / 02期

关键词：

rat brain; hyperpolarized xenon; brain perfusion; MR spectroscopy; MR imaging;

D O I：

10.1002/mrm.1180

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Hyperpolarized Xe-129 dissolved in a lipid emulsion constitutes an NMR tracer that can be injected into the blood stream, enabling blood-flow measurement and perfusion imaging. A small volume (0.15 ml) of this tracer was injected in 1.5 s in rat carotid and Xe-129 MR spectra and images were acquired at 2.35 T to evaluate the potential of this approach for cerebral studies. Xenon spectra consistently showed two resonances, at 194.5 ppm and 199.0 ppm relative to the gas peak. The signal-to-noise ratio (SNR) obtained for the two peaks was sufficient (ranging from 12 to 90) to follow their time courses. 2D transverse-projection xenon images were obtained with an in-plane resolution of 900 mum per pixel (SNR range 8-15). Histological analysis revealed no brain damage except in two rats that had received three injections. (C) 2001 Wiley-Liss, Inc.

引用

页码：208 / 212

页数：5

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