Discovery of a potent, orally active, nonsteroidal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6(trifluoromethyl)-8-pyridono[5,6-g]-quinoline (LG121071)

被引：80

作者：

Hamann, LG

Mani, NS

Davis, RL

Wang, XN

Marschke, KB

Jones, TK

机构：

[1] Ligand Pharmaceut Inc, Dept Med Chem, San Diego, CA 92121 USA

[2] Ligand Pharmaceut Inc, Dept Endocrine Res, San Diego, CA 92121 USA

[3] Ligand Pharmaceut Inc, Dept New Leads Discovery, San Diego, CA 92121 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 02期

关键词：

D O I：

10.1021/jm9806648

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：210 / 212

页数：3

共 46 条

[41]

STEIN RB, 1992, NEW DRUGS FROM NATURAL SOURCES, P13

[42] 5-benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists [J].

Tegley, CM ;

Zhi, L ;

Marschke, KB ;

Gottardis, MM ;

Yang, QC ;

Jones, TK .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (22) :4354-4359

[43]

TOOMEY D, 1995, CANCER-AM CANCER SOC, V76, P2418, DOI 10.1002/1097-0142(19951215)76:12<2418::AID-CNCR2820761204>3.0.CO

[44]

2-C

[45]

WILSON JD, 1996, GOODMAN GILMANS PHAR, P1441

[46] 5-aryl-1,2-dihydrochromeno[3,4-f]quinolines: A novel class of nonsteroidal human progesterone receptor agonists [J].

Zhi, L ;

Tegley, CM ;

Kallel, EA ;

Marschke, KB ;

Mais, DE ;

Gottardis, MM ;

Jones, TK .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (03) :291-302

← 1 2 3 4 5 →