Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides

被引：35

作者：

Cumming, JG

Cooper, AE

Grime, K

Logan, CJ

McLaughlin, S

Oldfield, J

Shaw, JS

Tucker, H

Winter, J

Whittaker, D

机构：

[1] AstraZeneca, Resp & Infammat Res Area, Macclesfield SK10 4TG, Cheshire, England

[2] AstraZeneca R&D Charnwood, Loughborough LE11 5RH, Leics, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 22期

关键词：

CCR5; chemokine receptor modulator;

D O I：

10.1016/j.bmcl.2005.08.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5 chemokine receptor. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5012 / 5015

页数：4

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