Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

被引：272

作者：

Thye, Thorsten ^{[1
,2
]}

Vannberg, Fredrik O. ^{[3
]}

Wong, Sunny H. ^{[3
]}

Owusu-Dabo, Ellis ^{[4
,5
]}

Osei, Ivy ^{[6
]}

Gyapong, John ^{[6
]}

Sirugo, Giorgio ^{[7
]}

Sisay-Joof, Fatou ^{[7
]}

Enimil, Anthony ^{[4
,8
]}

Chinbuah, Margaret A. ^{[6
]}

Floyd, Sian ^{[9
]}

Warndorff, David K. ^{[10
]}

Sichali, Lifted ^{[10
]}

Malema, Simon ^{[10
]}

Crampin, Amelia C. ^{[9
]}

Ngwira, Bagrey ^{[10
]}

Teo, Yik Y. ^{[3
]}

Small, Kerrin ^{[3
]}

Rockett, Kirk ^{[3
]}

Kwiatkowski, Dominic ^{[3
]}

Fine, Paul E. ^{[9
,10
]}

Hill, Philip C. ^{[7
]}

Newport, Melanie ^{[7
]}

Lienhardt, Christian ^{[7
]}

Adegbola, Richard A. ^{[7
]}

Corrah, Tumani ^{[7
]}

Ziegler, Andreas ^{[2
]}

Morris, Andrew P. ^{[3
]}

Meyer, Christian G. ^{[1
]}

Horstmann, Rolf D. ^{[1
]}

Hill, Adrian V. S. ^{[3
]}

机构：

[1] Bernhard Nocht Inst Trop Med, Dept Mol Med, Hamburg, Germany

[2] Univ Hosp Schleswig Holstein, Inst Med Biometry & Stat, Lubeck, Germany

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England

[4] Kumasi Ctr Collaborat Res Trop Med, Kumasi, Ghana

[5] Kwame Nkrumah Univ Sci & Technol, Coll Hlth Sci, Dept Community Hlth, Kumasi, Ghana

[6] Ghana Hlth Serv, Hlth Res Unit, Accra, Ghana

[7] Med Res Ctr Labs, Banjul, Gambia

[8] Komfo Anokye Teaching Hosp, Kumasi, Ghana

[9] London Sch Hyg & Trop Med, London WC1, England

[10] Karonga Prevent Study, Chilumba, Karonga Dist, Malawi

来源：

NATURE GENETICS | 2010年 / 42卷 / 09期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/ng.639

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

引用

页码：739 / 741

页数：3

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