The total synthesis of tritiated and deuterated 5-oxo-ETE, a novel inflammatory mediator

被引：17

作者：

Khanapure, SP

Shi, XX

Powell, WS

Rokach, J ^{[1
]}

机构：

[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA

[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA

[3] McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada

[4] McGill Univ, Resp Hlth Network Ctr Excellence, Montreal, PQ H2X 2P2, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 12期

关键词：

D O I：

10.1021/jo980280p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of 11,12,14,15-tetratritiated and deuterated 5-oxo-ETE is accomplished using a novel bisacetylene precursor 14. The syntheses of these labeled derivatives are necessary in order to investigate further the role and biochemistry of the novel inflammatory mediator and eosinophilic chemotactic agent 5-oxo-ETE.

引用

页码：4098 / 4102

页数：5

共 19 条

[1]

COREY EJ, 1981, TETRAHEDRON LETT, P299

[2] Chemotactic 5-oxo-eicosatetraenoic acids induce oxygen radical production, Ca2+-mobilization, and actin reorganization in human eosinophils via a pertussis toxin-sensitive G-protein [J].