Isocitrate lyase (AceA) is required for Salmonella persistence but not for acute lethal infection in mice

被引：88

作者：

Fang, FC

Libby, SJ

Castor, ME

Fung, AM

机构：

[1] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 04期

关键词：

D O I：

10.1128/IAI.73.4.2547-2549.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Isocitrate lyase is required for fatty acid utilization via the glyoxylate shunt. Although isocitrate lyase is essential for Salmonella persistence during chronic infection, it is dispensable for acute lethal infection in mice. Substrate availability in the phagosome appears to evolve over time, with increasing fatty acid dependence during chronic infection.

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页码：2547 / 2549

页数：3

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