Products of cytochrome P450Biol (CYP107H1)-catalyzed oxidation of fatty acids

被引：51

作者：

Cryle, MJ ^{[1
]}

Matovic, NJ ^{[1
]}

De Voss, JJ ^{[1
]}

机构：

[1] Univ Queensland, Dept Chem, St Lucia, Qld 4072, Australia

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol035254e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450(Biol) (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C-14 fatty acids and the 11- to 15-hydroxy C-16 fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450(Biol) was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.

引用

页码：3341 / 3344

页数：4

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