Oxidizing species in the mechanism of cytochrome P450

被引：279

作者：

de Montellano, PRO ^{[1
]}

De Voss, JJ

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[2] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia

来源：

NATURAL PRODUCT REPORTS | 2002年 / 19卷 / 04期

关键词：

D O I：

10.1039/b101297p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review discusses the mechanisms of oxygen activation by cytochrome P450 enzymes, the possible catalytic roles of the various iron-oxygen species formed in the catalytic cycle, and progress in understanding the mechanisms of hydrocarbon hydroxylation, heteroatom oxidation, and olefin epoxidation. The focus of the review is on recent results, but earlier work is discussed as appropriate. The literature through to February 2002 is surveyed, and 175 referenced are cited.

引用

页码：477 / 493

页数：17

共 180 条

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