Preparation and characterization of novel semi-interpenetrating 2-hydroxyethyl methacrylate-&chitosan copolymeric microspheres for sustained release of indomethacin

被引：7

作者：

Babu, V. Ramesh ^{[1
]}

Sairam, M. ^{[1
]}

Hosamani, K. M. ^{[1
]}

Aminabhavi, T. M. ^{[1
]}

机构：

[1] Karnatak Univ, Ctr Excellence Polymer Sci, Drug Delivery Div, Dharwad 580003, Karnataka, India

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2007年 / 106卷 / 06期

关键词：

chitosan; 2-hydroxyethyl methacrylate; semiIPN; microspheres; indomethacin; sustained release;

D O I：

10.1002/app.25453

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理]; 080501 [材料物理与化学]; 081704 [应用化学];

摘要：

A novel semi-interpenetrating (semi-IPN) graft copolymer of 2-hydroxyethyl methacrylate (HEMA) with chitosan (CS) has been prepared in the form of microspheres, using water-in-oil (W/O) emulsion technique. Microspheres were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC, and X-ray diffractometry (X-RD) to confirm the crosslinking and polymorphism of indomethacin (IDM). The X-RD and DSC techniques indicated a molecular-level dispersion of IDM in the lPN matrix. Scanning electron micrographs (SEM) taken at the cross section of the micro-spheres have shown rough surfaces around the microspheres. The sustained release characteristics of the matrices for IDM, an anti-inflammatory drug, were investigated in pH 7.4 media. Particle size and size distribution of the microspheres were studied by laser light diffraction particle size analyzer. The drug was released in a sustained manner for up to 12 h.

引用

页码：3778 / 3785

页数：8

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