Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity

被引：54

作者：

Centerwall, CR ^{[1
]}

Goodisman, J ^{[1
]}

Kerwood, DJ ^{[1
]}

Dabrowiak, JC ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 37期

关键词：

D O I：

10.1021/ja053353c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin. Copyright © 2005 American Chemical Society.

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页码：12768 / 12769

页数：2

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