mTOR Signaling in Growth Control and Disease

被引：7030

作者：

Laplante, Mathieu ^{[1
,2
,3
]}

Sabatini, David M. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] MIT, Koch Ctr Integrat Canc Res, Cambridge, MA 02139 USA

来源：

CELL | 2012年 / 149卷 / 02期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

EXTENDS LIFE-SPAN; P70; S6; KINASE; TUBEROUS SCLEROSIS COMPLEX-2; CELL-CYCLE PROGRESSION; DIET-INDUCED OBESITY; MAMMALIAN TARGET; INSULIN-RESISTANCE; AMINO-ACIDS; SKELETAL-MUSCLE; OXIDATIVE-PHOSPHORYLATION;

D O I：

10.1016/j.cell.2012.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

引用

页码：274 / 293

页数：20

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