The CASP8-652 6N del promoter polymorphism and breast cancer risk:: a multicenter study

被引：47

作者：

Frank, Bernd ^{[1
,2
]}

Rigas, Sushila H. ^{[3
]}

Bermejo, Justo Lorenzo ^{[2
]}

Wiestler, Miriam ^{[1
,2
]}

Wagner, Kerstin ^{[2
]}

Hemminki, Kari ^{[2
,4
]}

Reed, Malcolm W. ^{[5
]}

Sutter, Christian ^{[6
]}

Wappenschmidt, Barbara ^{[7
]}

Balasubramanian, Sabapathy P. ^{[5
]}

Meindl, Alfons

Kiechle, Marion

Bugert, Peter

Schmutzler, Rita K. ^{[7
]}

Bartram, Claus R. ^{[6
]}

Justenhoven, Christina

Ko, Yon-Dschun

Bruening, Thomas

Brauch, Hiltrud

Hamann, Ute

Pharoah, Paul P. D.

Dunning, Alison M.

Pooley, Karen A.

Easton, Douglas F.

Cox, Angela ^{[3
]}

Burwinkel, Barbara ^{[1
,2
]}

机构：

[1] Helmholtz Univ Grp Mol Epidemiol, German Canc Res Ctr, DKFZ, D-69120 Heidelberg, Germany

[2] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany

[3] Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield, S Yorkshire, England

[4] Karolinska Inst, Ctr Family Med, Huddinge, Sweden

[5] Univ Sheffield, Sch Med, Acad Unit Surg Oncol, Sheffield, S Yorkshire, England

[6] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

[7] Univ Cologne, Ctr Clin, Dept Obstet & Gynaecol, Div Mol Gynaecooncol, Cologne, Germany

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 111卷 / 01期

关键词：

deletion; CASP8-652 6N del; Sp1 binding site; apoptosis; breast cancer risk;

D O I：

10.1007/s10549-007-9752-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans.

引用

页码：139 / 144

页数：6