Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9

被引:54
作者
Bauer, Stefan [1 ]
Pigisch, Stephanie [2 ]
Hangel, Doris [2 ]
Kaufmann, Andreas [1 ]
Hamm, Svetlana [2 ]
机构
[1] Univ Marburg, Inst Immunol, BMFZ, D-35043 Marburg, Germany
[2] Tech Univ Munich, Inst Med Mikrobiol Immunol & Hyg, D-81675 Munich, Germany
关键词
Toll-like receptors; imidazoquinoline; RNA; CpG-DNA;
D O I
10.1016/j.imbio.2007.10.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The mammalian immune system senses pathogens through pattern recognition receptors (PRR) and responds with activation. Toll-like receptors (TLRs) that are expressed on immune and non-immune cells play a critical role in this process. As part of the innate immune response, TLRs lead to cellular activation and cytokine production with subsequent initiation of an adaptive immune response. TLR7-9 recognize single-stranded RNA, nucleoside analogs and single-stranded CpG-DNA, respectively, and their activation initiates the immune response against viruses and bacteria. Furthermore, the stimulation of these TLRs may be exploited for adjuvant therapy, vaccination and antitumor responses. However, a role in the generation or perpetuation of autoimmune diseases such as systemic lupus erythematosus (SLE) has also been suggested. (C) 2007 Elsevier GmbH. All rights reserved.
引用
收藏
页码:315 / 328
页数:14
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