Electroencephalographic measures of regional hemispheric activity in offspring at risk for depressive disorders

被引:94
作者
Bruder, GE
Tenke, CE
Warner, V
Nomura, Y
Grillon, C
Hille, J
Leite, P
Weissman, MM
机构
[1] New York State Psychiat Inst & Hosp, Dept Biopsychol, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA
[3] New York State Psychiat Inst & Hosp, Dept Clin & Genet Epidemiol, New York, NY 10032 USA
[4] NIMH, Anxiety Disorders Res Program, Bethesda, MD 20892 USA
[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
关键词
alpha power; EEG; hemispheric asymmetry; high risk; major depressive disorder;
D O I
10.1016/j.biopsych.2004.11.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Electroencephalographic (EEG) studies have found abnormal regional hemispheric asymmetries in depressive disorders which have been hypothesized to be vulnerability markers for depression, In a longitudinal high-risk study, resting EEG was measured in primarily adult offspring of depressed or nondepressed probands. Methods:. Electroencephalograms from 12 homologous sites over each hemisphere (digitally linked-ears reference) were analyzed in right-handed offspring for whom both parents (n = 18), one parent (n = 40), or neither parent (n = 29) had a major depressive disorder (MDD). Results: Offspring with both parents having MDD showed greater alpha asymmetry at medial sites, with relatively less activity (more offspring having one or no parent with MDD. Relatively less left frontal alpha) over fight central and parietal regions, compared with of activity at lateral sites was associated with lifetime MDD in offspring but not with parental MDD. Offspring with both parents having a MDD also showed markedly greater anterior-to-posterior increase in alpha with eyes closed compared with those with one or no parent with a MDD. Conclusions: Alpha asymmetry indicative of right parietotemporal hypoactivity, previously reported fir depressed adolescents and adults, and heightened anterior-to-posterior gradient of alpha are present in high-risk offspring having parents concordant for MDD.
引用
收藏
页码:328 / 335
页数:8
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