Attacking pain at its source:: new perspectives on opioids

被引：448

作者：

Stein, C ^{[1
]}

Schäfer, M ^{[1
]}

Machelska, H ^{[1
]}

机构：

[1] Free Univ Berlin, Klinikum Benjamin Franklin, Klin Anaesthesiol & Operat Intens Med, D-12200 Berlin, Germany

来源：

NATURE MEDICINE | 2003年 / 9卷 / 08期

关键词：

D O I：

10.1038/nm908

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide-containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.

引用

页码：1003 / 1008

页数：6

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