Peptide-size -: dependent active transport in the proteasome

被引：8

作者：

Zaikin, A

Pöschel, T

机构：

[1] Humboldt Univ, Charite, Inst Biochem, D-10117 Berlin, Germany

[2] Univ Exeter, Dept Math Sci, Exeter EX4 4QE, Devon, England

来源：

EUROPHYSICS LETTERS | 2005年 / 69卷 / 05期

关键词：

D O I：

10.1209/epl/i2004-10426-8

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigate the transport of proteins inside the proteasome and propose an active-transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size-dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.

引用

页码：725 / 731

页数：7

共 35 条

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