Peptide-size -: dependent active transport in the proteasome

被引：8

作者：

Zaikin, A

Pöschel, T

机构：

[1] Humboldt Univ, Charite, Inst Biochem, D-10117 Berlin, Germany

[2] Univ Exeter, Dept Math Sci, Exeter EX4 4QE, Devon, England

来源：

EUROPHYSICS LETTERS | 2005年 / 69卷 / 05期

关键词：

D O I：

10.1209/epl/i2004-10426-8

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We investigate the transport of proteins inside the proteasome and propose an active-transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size-dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.

引用

页码：725 / 731

页数：7

共 35 条

[31] Tama F, 2000, PROTEINS, V41, P1
[32] Vale R D, 1990, Adv Biophys, V26, P97, DOI 10.1016/0065-227X(90)90009-I
[33] van Kampen N.G., 1981, Stochastic Processes in Physics and Chemistry
[34] 26S proteasome structure revealed by three-dimensional electron microscopy
Walz, J
Erdmann, A
Kania, M
Typke, D
Koster, AJ
Baumeister, W
[J]. JOURNAL OF STRUCTURAL BIOLOGY, 1998, 121 (01) : 19 - 29
[35] Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
Wyttenbach, A
Carmichael, J
Swartz, J
Furlong, RA
Narain, Y
Rankin, J
Rubinsztein, DC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) : 2898 - 2903

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