Adipose tissue is a regulated source of interleukin-10

被引：120

作者：

Juge-Aubry, CE

Somm, E

Pernin, A

Alizadeh, N

Giusti, V

Dayer, JM

Meier, CA

机构：

[1] Univ Hosp Geneva, Endocrine Unit, Dept Internal Med, Div Immunol & Allergy, CH-1211 Geneva, Switzerland

[2] Univ Hosp Geneva, Dept Surg, Div Reconstruct Surg, Plast Reconstruct Surg Unit, CH-1211 Geneva, Switzerland

[3] Geneva Sch Med, Dept Med, Mol Endocrinol Lab, CH-1211 Geneva, Switzerland

[4] Geneva Sch Med, Dept Cellular Physiol & Metab, CH-1211 Geneva, Switzerland

[5] Univ Hosp Geneva, Dept Med, Div Endocrinol Diabetol & Metab, CH-1011 Lausanne, Switzerland

来源：

CYTOKINE | 2005年 / 29卷 / 06期

关键词：

adipose tissue; antiinflammatory; cytokine; interleukin-10; obesity;

D O I：

10.1016/j.cyto.2004.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase). (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：270 / 274

页数：5

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