Adipose tissue is a regulated source of interleukin-10

被引：120

作者：

Juge-Aubry, CE

Somm, E

Pernin, A

Alizadeh, N

Giusti, V

Dayer, JM

Meier, CA

机构：

[1] Univ Hosp Geneva, Endocrine Unit, Dept Internal Med, Div Immunol & Allergy, CH-1211 Geneva, Switzerland

[2] Univ Hosp Geneva, Dept Surg, Div Reconstruct Surg, Plast Reconstruct Surg Unit, CH-1211 Geneva, Switzerland

[3] Geneva Sch Med, Dept Med, Mol Endocrinol Lab, CH-1211 Geneva, Switzerland

[4] Geneva Sch Med, Dept Cellular Physiol & Metab, CH-1211 Geneva, Switzerland

[5] Univ Hosp Geneva, Dept Med, Div Endocrinol Diabetol & Metab, CH-1011 Lausanne, Switzerland

来源：

CYTOKINE | 2005年 / 29卷 / 06期

关键词：

adipose tissue; antiinflammatory; cytokine; interleukin-10; obesity;

D O I：

10.1016/j.cyto.2004.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase). (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：270 / 274

页数：5

共 21 条

[11] Regulatory effects of interleukin (IL)-1, interferon-β, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue
Juge-Aubry, CE
Somm, E
Chicheportiche, R
Burger, D
Pernin, A
Cuénod-Pittet, B
Quinodoz, P
Guisti, V
Dayer, JM
Meier, CA
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) : 2652 - 2658
[12] Adipose tissue is a major source of interleukin-1 receptor antagonist - Upregulation in obesity and inflammation
Juge-Aubry, CE
Somm, E
Giusti, V
Pernin, A
Chicheportiche, R
Verdumo, C
Rohner-Jeanrenaud, F
Burger, D
Dayer, JM
Meier, CA
[J]. DIABETES, 2003, 52 (05) : 1104 - 1110
[13] Leptin actions on food intake and body temperature are mediated by IL-1
Luheshi, GN
Gardner, JD
Rushforth, DA
Loudon, AS
Rothwell, NJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) : 7047 - 7052
[14] IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
Matsuki, T
Horai, R
Sudo, K
Iwakura, Y
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (06) : 877 - 888
[15] IL-1 receptor antagonist serum levels are increased in human obesity: A possible link to the resistance to leptin?
Meier, CA
Bobbioni, E
Gabay, C
Assimacopoulos-Jeannet, F
Golay, A
Dayer, JM
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (03) : 1184 - 1188
[16] Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
Nicklin, MJH
Hughes, DE
Barton, JL
Ure, JM
Duff, GW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) : 303 - 311
[17] Interleukin-10 blocks atherosclerotic events in vitro and in vivo
Oslund, LJP
Hedrick, CC
Olvera, T
Hagenbaugh, A
Territo, M
Berliner, JA
Fyfe, AI
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (12) : 2847 - 2853
[18] Monocyte chemoattractant protein 1 in obesity and insulin resistance
Sartipy, P
Loskutoff, DJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (12) : 7265 - 7270
[19] Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes -: The Leiden 85-plus study
van Exel, E
Gussekloo, J
de Craen, AJM
Frölich, M
Bootsma-van der Wiel, A
Westendorp, RGJ
[J]. DIABETES, 2002, 51 (04) : 1088 - 1092
[20] VANEXEL E, 2004, INFLAMMATION STROKE, V33, P1135

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