A Robust Electronic Switch Made of Immobilized Duplex/Quadruplex DNA

被引：74

作者：

Ge, Bixia ^{[2
]}

Huang, Yu Chuan ^{[1
]}

Sen, Dipankar ^{[1
]}

Yu, Hua-Zhong ^{[2
]}

机构：

[1] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

[2] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 51期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

DNA; electrochemistry; G-quadruplexes; nanotechnology; switches; RESONANCE ENERGY-TRANSFER; TELOMERIC REPEAT; POTASSIUM-IONS; QUADRUPLEX; SENSORS; RECOGNITION; THROMBIN; POLYMER; COMPLEX; DUPLEX;

D O I：

10.1002/anie.201004946

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Flicking a switch: A robust DNA nanoswitch has been designed by using a contractile DNA construct (G-quadruplex) as the switch medium and ferrocene (Fc) as a redox-active indicator (see picture). The switch was electrochemically tested and can be turned "on" or "off" repeatedly by the addition or removal, respectively, of the effector (K+ ions). The reversibility and repeatability of the DNA switch are directly monitored by electrochemical measurements. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9965 / 9967

页数：3

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