Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli

被引：75

作者：

Sakamoto, Y ^{[1
]}

Furukawa, S ^{[1
]}

Ogihara, H ^{[1
]}

Yamasaki, M ^{[1
]}

机构：

[1] Nihon Univ, Dept Food Sci & Technol, Coll Bioresouce Sci, Fujisawa, Kanagawa 2528510, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 09期

关键词：

fosmidomycin; cAMP; Escherichia coli; DNA micro-array;

D O I：

10.1271/bbb.67.2030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.

引用

页码：2030 / 2033

页数：4

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