A highly efficient asymmetric synthesis of beta-aminophosphonic acids via addition of alpha-phosphonate carbanions to chiral, enantiopure sulfinimines

被引：42

作者：

Mikolajczyk, M ^{[1
]}

Lyzwa, P ^{[1
]}

Drabowicz, J ^{[1
]}

Wieczorek, MW ^{[1
]}

Blaszczyk, J ^{[1
]}

机构：

[1] TECH UNIV LODZ,INST TECH BIOCHEM,PL-90924 LODZ,POLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 13期

关键词：

D O I：

10.1039/cc9960001503

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Addition of alpha-phosphonate carbanions to (S)-sulfinimines 1 affords N-sulfinyl beta-aminophosphonates 2 in a diastereoisomeric ratio from 5:1 to 10:1; the major diastereoisomers of 2, after separation, are converted to the corresponding beta-aminophosphonates 3 or to (+)-beta-amino-beta-phenylethane phosphonic acid 4, whose absolute configuration was established as (R) by X-ray crystallography.

引用

页码：1503 / 1504

页数：2

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