The roles of cells and cytokines in the pathogenesis of psoriasis

被引:143
作者
Coimbra, Susana [1 ,2 ,3 ]
Figueiredo, Americo [4 ]
Castro, Elisabeth [2 ]
Rocha-Pereira, Petronila [2 ,5 ]
Santos-Silva, Alice [2 ]
机构
[1] Univ Porto, Fac Farm, Serv Bioquim, Biochem Lab,Dept Biol Sci, P-4050047 Oporto, Portugal
[2] Univ Porto, IBMC, P-4050047 Oporto, Portugal
[3] CESPU, Cooperat Higher Educ Polytech & Univ, CITS, No Polytech Hlth Inst, Gandra Paredes, Portugal
[4] Coimbra Univ Hosp, Dermatol Serv, Coimbra, Portugal
[5] Univ Beira Interior, CICS, Covilha, Portugal
关键词
ENDOTHELIAL GROWTH-FACTOR; BLOOD MONONUCLEAR-CELLS; TUMOR-NECROSIS-FACTOR; T-CELLS; TNF-ALPHA; DENDRITIC CELLS; SERUM-LEVELS; IFN-GAMMA; INTERFERON-GAMMA; DISEASE SEVERITY;
D O I
10.1111/j.1365-4632.2011.05154.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100227 [皮肤病学];
摘要
Psoriasis is considered an immune chronic disease in which T cells are accepted as important. Nowadays, it is believed that psoriasis is most likely a T helper (Th)1/Th17 induced inflammatory disease. However, some other cells, such as endothelial cells, dendritic cells, monocytic cells, neutrophils, keratinocytes, and several cytokines, appear to have, at different stages of the disease, an important role in its pathogenesis. For instance, the response to psoriasis therapy is dependent not only on the inactivation of Th1 and Th17 immune responses but also on the inactivation of dendritic cell products. Moreover, interleukin (IL)-23 deregulation appears to be an independent factor in the pathogenesis of psoriasis. Indeed, currently, the IL-23/Th17 axis is believed to be crucial in psoriasis pathogenesis, and its inhibition appears to be important for therapeutic achievement. This review presents the roles and interactions of cells and cytokines that are related to psoriasis pathogenesis.
引用
收藏
页码:389 / 398
页数:10
相关论文
共 64 条
[1]
Serum levels of proinflammatory cytokines in psoriasis patients from Saudi Arabia [J].
Abanmi, A ;
Al Harthi, F ;
Khan, HA ;
Tariq, M .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2005, 44 (01) :82-83
[2]
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17 [J].
Aggarwal, S ;
Ghilardi, N ;
Xie, MH ;
de Sauvage, FJ ;
Gurney, AL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1910-1914
[3]
Serum levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17 and IL-18 in patients with active psoriasis and correlation with disease severity [J].
Arican, O ;
Aral, M ;
Sasmaz, S ;
Ciragil, P .
MEDIATORS OF INFLAMMATION, 2005, (05) :273-279
[4]
Developments in systemic immunomodulatory therapy for psoriasis [J].
Berger, Emily M. ;
Gottlieb, Alice B. .
CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (04) :434-444
[5]
Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis [J].
Bhushan, M ;
McLaughlin, B ;
Weiss, JB ;
Griffiths, CEM .
BRITISH JOURNAL OF DERMATOLOGY, 1999, 141 (06) :1054-1060
[6]
Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2 [J].
Biedermann, T ;
Kneilling, M ;
Mailhammer, R ;
Maier, K ;
Sander, CA ;
Kollias, G ;
Kunkel, SL ;
Hültner, L ;
Röcken, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1441-1451
[8]
Boniface K, 2005, EUR CYTOKINE NETW, V16, P309
[9]
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis [J].
Capon, Francesca ;
Di Meglio, Paola ;
Szaub, Joanna ;
Prescott, Natalie J. ;
Dunster, Christina ;
Baumber, Laura ;
Gutin, Alexander ;
Abkevic, Victor ;
Burden, A. David ;
Lanchbury, Jerry ;
Barker, Jonathan N. ;
Trembath, Richard C. ;
Nestle, Frank O. .
HUMAN GENETICS, 2007, 122 (02) :201-206
[10]
Serum Levels of IL-17 and IL-22 Are Reduced by Etanercept, but not by Acitretin, in Patients with Psoriasis: a Randomized-Controlled Trial [J].
Caproni, M. ;
Antiga, E. ;
Melani, L. ;
Volpi, W. ;
Del Bianco, E. ;
Fabbri, P. .
JOURNAL OF CLINICAL IMMUNOLOGY, 2009, 29 (02) :210-214