Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines

被引：167

作者：

Cserni, G ^{[1
]}

Amendoeira, I

Apostolikas, N

Bellocq, JP

Bianchi, S

Bussolati, G

Boecker, W

Borisch, B

Connolly, CE

Decker, T

Dervan, P

Drijkoningen, M

Ellis, IO

Elston, CW

Eusebi, V

Faverly, D

Heikkila, P

Holland, R

Kerner, H

Kulka, J

Jacquemier, J

Lacerda, M

Martinez-Penuela, J

De Miguel, C

Peterse, JL

Rank, F

Regitnig, P

Reiner, A

Sapino, A

Sigal-Zafrani, B

Tanous, AM

Thorstenson, S

Zozaya, E

Wells, CA

机构：

[1] Bacs Kiskun Cty Teaching Hosp, Dept Pathol, Keeskemet, Hungary

[2] Univ Porto, Inst Patol & Imunol Mol, Dept Pathol, P-4100 Oporto, Portugal

[3] St Savvas Hosp, Dept Pathol, Athens, Greece

[4] Hop Hautepierre, Serv Anat Pathol, Strasbourg, France

[5] Univ Florence, Dept Human Pathol & Oncol, Florence, Italy

[6] Ist Anat & Istol Patol, Turin, Italy

[7] Univ Munster, Gerhard Domagk Inst Pathol, D-4400 Munster, Germany

[8] Ctr Med Univ Geneva, CH-1211 Geneva, Switzerland

[9] Univ Coll Hosp Galway, Inst Clin Sci, Dept Pathol, Galway, Ireland

[10] HELIOS Med Ctr, Brest Unit, Dept Pathol, Berlin, Germany

[11] Mater Misericordiae Univ Hosp, Dept Pathol, Dublin 7, Ireland

[12] Univ Hosp, Pathol Ontleedkunde, Louvain, Belgium

[13] City Hosp, Dept Histopathol, Nottingham NG5 1PB, England

[14] Univ Bologna, Osped Bellaria, Sez Anat Patol M Malpighi, I-40139 Bologna, Italy

[15] CMP Lab, Brussels, Belgium

[16] Univ Helsinki, Haartman Inst, FIN-00014 Helsinki, Finland

[17] Acad Ziekenhuis, Natl Expert & Training Ctr Creast Canc Screening, Nijmegen, Netherlands

[18] Rambam Med Ctr, Dept Pathol, Haifa, Israel

[19] Semmelweis Univ, Inst Pathol 2, H-1085 Budapest, Hungary

[20] Inst J Paoli I Calmettes, F-13009 Marseille, France

[21] Ctr Reg Oncol Coimbra, Lab Histopatol, Coimbra, Portugal

[22] Hosp Navarra, Dept Pathol, Pamplona, Spain

[23] Hosp Virgen Camino, Dept Pathol, Pamplona, Spain

[24] Netherlands Canc Inst, Dept Pathol, NL-1066 CX Amsterdam, Netherlands

[25] Univ Copenhagen Hosp, Rigshosp, Dept Pathol, Ctr Lab Med & Pathol, DK-2100 Copenhagen, Denmark

[26] Karl Franzens Univ Graz, Inst Pathol, A-8010 Graz, Austria

[27] Donauspital, Inst Pathol, Vienna, Austria

[28] Inst Curie, Sect Med & Hosp, Paris, France

[29] Lab Natl Sante, Div Anat Pathol, Luxembourg, Luxembourg

[30] Kalmar Cty Hosp, Kalmar, Sweden

[31] St Bartholomews Hosp, Sch Med, Dept Histopathol, London, England

来源：

EUROPEAN JOURNAL OF CANCER | 2003年 / 39卷 / 12期

关键词：

sentinel lymph nodes; breast cancer; micrometastasis; isolated tumour cell; occult metastasis; survival; non-sentinel node metastasis; frozen section; intraoperative cytology; molecular analysis;

D O I：

10.1016/S0959-8049(03)00203-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Controversies and inconsistencies regarding the pathological work-LIP of sentinel lymph nodes (SNs) led the European Working Group for Breast Screening Pathology (EWGBSP) to review published data and current evidence that can promote the formulation of European guidelines for the pathological work-up of SNs. After an evaluation of the accuracy of SN biopsy as a staging procedure, the yields of different sectioning methods and the immunohistochemical detection of metastatic cells are reviewed. Currently published data do not allow the significance of micrometastases or isolated tumour cells to be established, but it is suggested that approximately 18% of the cases may be associated with further nodal (non-SN) metastases, i.e. approximately 2% of all patients initially staged by SN biopsy. The methods for the intraoperative and molecular assessment of SNs are also surveyed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1654 / 1667

页数：14

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