Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

被引:378
作者
Galan, Jorge E. [1 ]
Lara-Tejero, Maria [1 ]
Marlovits, Thomas C. [2 ,3 ,4 ,5 ]
Wagner, Samuel [6 ]
机构
[1] Yale Univ, Sch Med, Dept Microbial Pathogenesis, New Haven, CT 06536 USA
[2] Univ Med Ctr Hamburg Eppendorf, Ctr Struct Syst Biol, D-20246 Hamburg, Germany
[3] DESY, D-20246 Hamburg, Germany
[4] Austrian Acad Sci, Inst Mol Biotechnol GmbH, A-1030 Vienna, Austria
[5] Res Inst Mol Pathol, A-1030 Vienna, Austria
[6] Univ Tubingen, Interfac Inst Microbiol & Infect Med, D-72076 Tubingen, Germany
来源
ANNUAL REVIEW OF MICROBIOLOGY, VOL 68 | 2014年 / 68卷
基金
美国国家卫生研究院;
关键词
protein secretion; bacterial pathogenesis; molecular machines; YOP TRANSLOCATION PORE; MESSENGER-RNA SIGNAL; SALMONELLA-TYPHIMURIUM; YERSINIA-ENTEROCOLITICA; ESCHERICHIA-COLI; NEEDLE COMPLEX; SUBSTRATE-SPECIFICITY; EPITHELIAL-CELLS; GENETIC-ANALYSIS; INNER-ROD;
D O I
10.1146/annurev-micro-092412-155725
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. One of these protein-delivery machines is the type III secretion system (T3SS). T3SSs are widespread in nature and are encoded not only by bacteria pathogenic to vertebrates or plants but also by bacteria that are symbiotic to plants or insects. A central component of T3SSs is the needle complex, a supramolecular structure that mediates the passage of the secreted proteins across the bacterial envelope. Working in conjunction with several cytoplasmic components, the needle complex engages specific substrates in sequential order, moves them across the bacterial envelope, and ultimately delivers them into eukaryotic cells. The central role of T3SSs in pathogenesis makes them great targets for novel antimicrobial strategies.
引用
收藏
页码:415 / 438
页数:24
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