Neurotrophic Schwann-cell factors induce neural differentiation of bone marrow stromal cells

被引:57
作者
Zurita, Mercedes
Vaquero, Jesus
Oya, Santiago
Bonilla, Celia
Aguayo, Concepcion
机构
[1] Autonomous Univ Madrid, Mapfre Fdn, Neurosci Res Unit, Madrid 28035, Spain
[2] Autonomous Univ Madrid, Puerta Hierro Hosp, Neurosurg Serv, Madrid, Spain
关键词
bone marrow stromal cells; neural differentiation; Schwann cells; stem cells;
D O I
10.1097/WNR.0b013e3282f0d3b0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neural transdifferentiation of bone marrow stromal cells has been questioned, because cell fusion could explain the development of new cell types, misinterpreted as transdifferentiated cells. We performed here cocultures of bone marrow stromal cells and Schwann cells, without possibility that both cell types can establish contact. In these conditions, bone marrow stromal cells expressed nestin 4 h after beginning cocultures, and strong expression of neuronal markers was disclosed at 72 h, increasing at I and 2 weeks. Our results support that neural transdifferentiation of bone marrow stromal cells is induced by soluble factors provided by glial cells, and suggest that cell fusion should not be significant when local bone marrow stromal cells administration for neural repair is considered. (C) 2007 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:1713 / 1717
页数:5
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