Thermo and pH dual-responsive nanoparticles for anti-cancer drug delivery

被引：228

作者：

Zhang, Leyang

Guo, Rui

Yang, Mi

Jiang, Xiqun ^{[1
]}

Liu, Baorui

机构：

[1] Nanjing Univ, Coll Chem & Chem Engn, Mesoscop Chem Lab, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Coll Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Med Coll, Affiliated Drum Tower Hosp, Dept Oncol, Nanjing 210093, Peoples R China

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 19期

关键词：

D O I：

10.1002/adma.200601817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermo and pH dual-responsive nanoparticles encapsulating an anticancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co -acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery.

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页码：2988 / +

页数：6

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