The Drosophila protein Dof is specifically required for FGF signaling

被引：138

作者：

Vincent, S

Wilson, R

Coelho, C

Affolter, M

Leptin, M

机构：

[1] Univ Cologne, Inst Genet, D-50931 Cologne, Germany

[2] Univ Basel, Biozentrum, Abt Zellbiol, CH-4053 Basel, Switzerland

来源：

MOLECULAR CELL | 1998年 / 2卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(00)80151-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Receptor tyrosine kinases (RTKs) transmit signals to the cell nucleus via the MAP kinase (MAPK) cascade, using specific molecules to link the activated receptors to the MAPK cascade activator, Ras. We have identified a component of the FGF receptor (FGFR) signal transduction pathway, Downstream of FGFR (Dof). Dof is an intracellular protein that is essential for signal transmission by the FGFR and acts downstream of the receptor and upstream of Ras. Unlike other signaling molecules that act downstream of RTKs, Dof is not expressed ubiquitously but is present exclusively in cells that express FGFRs. Dof is needed in these cells for activation of the MAPK cascade via FGF signaling, but not for activation via other RTK ligands. Dof therefore appears to be committed exclusively to FGFR-mediated signal transduction.

引用

页码：515 / 525

页数：11

共 48 条

[11]

Gabay L, 1997, DEVELOPMENT, V124, P3535

[12] In situ activation pattern of Drosophila EGF receptor pathway during development [J].