Identification of new flaviviruses in the Kokobera virus complex

被引：24

作者：

Nisbet, DJ

Lee, KJ

van den Hurk, AF

Johansen, CA

Kuno, G

Chang, GJJ

Mackenzie, JS

Ritchie, SA

Hall, RA ^{[1
]}

机构：

[1] Univ Queensland, Sch Mol & Microbial Sci, Dept Microbiol & Parasitol, St Lucia, Qld 4072, Australia

[2] Ctr Dis Control & Prevent, Arbovirus Dis Branch, Div Vector Borne Infect Dis, Natl Ctr Infect Dis, Ft Collins, CO 80522 USA

[3] Trop Publ Hlth Unit, Cairns, Qld 4870, Australia

[4] James Cook Univ N Queensland, Sch Publ Hlth & Trop Med, Cairns, Qld 4870, Australia

来源：

JOURNAL OF GENERAL VIROLOGY | 2005年 / 86卷

关键词：

D O I：

10.1099/vir.0.80381-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novel flavivirus isolates from mosquitoes collected in northern Australia were analysed by partial genomic sequencing, monoclonal antibody-binding assays and polyclonal cross-neutralization tests. Two isolates were found to be antigenically distinct from, but related to, viruses of the Kokobera virus complex, which currently contains Kokobera (KOKV) and Stratford (STRV) viruses. Nucleotide sequence comparison of two separate regions of the genome revealed that an isolate from Saibai Island in the Torres Strait in 2000 (TS5273) was related closely to KOKV and STRV, with 74-80 and 75-76% nucleotide similarity, respectively. An isolate from mainland Cape York in 1998 (CY1014) was found to be more divergent from KOKV and STRV, with <70% nucleotide sequence similarity to either virus. It is proposed that isolate TS5273 represents a new subtype of KOKV and that CY1014 be classified as a novel species within the Kokobera virus complex of flaviviruses, named New Mapoon virus.

引用

页码：121 / 124

页数：4

共 25 条

[1] ILLNESS CAUSED BY A KOKOBERA-LIKE VIRUS IN SOUTHEASTERN AUSTRALIA [J].