Soluble HLA class I/CD8 ligation triggers apoptosis in EBV-specific CD8+ cytotoxic T lymphocytes by Fas/Fas-ligand interaction

被引:25
作者
Contini, P
Ghio, M
Merlo, A
Brenci, S
Filaci, G
Indiveri, F
Puppo, F
机构
[1] Univ Genoa, Dept Internal Med, I-16126 Genoa, Italy
[2] Univ Genoa, Dept Expt Med, Genoa, Italy
关键词
HLA; Fas/Fas-L; apoptosis; CTL; EBV;
D O I
10.1016/S0198-8859(00)00212-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the present study, we report that allogenic soluble HLA class I(sHLA-I) molecules isolated from serum induce apoptosis on EBV-specific CD8(+) Fas(+) cytotoxic T lymphocytes (CTL). CTL apoptosis is induced by thc binding of sHLA-I molecules to CD8 and its extent depends on the time of incubation with sHLA-I molecules. Apoptosis is triggered by the interaction of Fas(+) CTL with soluble Fas-ligand, which is released following che binding of sHLA-I antigens to CD8 molecules. These results suggest that sHLA-I molecules may regulate immune responses by inducing apoptosis in virus-specific CTL. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.
引用
收藏
页码:1347 / 1351
页数:5
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