Soluble HLA class I/CD8 ligation triggers apoptosis in EBV-specific CD8+ cytotoxic T lymphocytes by Fas/Fas-ligand interaction

被引:25
作者
Contini, P
Ghio, M
Merlo, A
Brenci, S
Filaci, G
Indiveri, F
Puppo, F
机构
[1] Univ Genoa, Dept Internal Med, I-16126 Genoa, Italy
[2] Univ Genoa, Dept Expt Med, Genoa, Italy
关键词
HLA; Fas/Fas-L; apoptosis; CTL; EBV;
D O I
10.1016/S0198-8859(00)00212-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the present study, we report that allogenic soluble HLA class I(sHLA-I) molecules isolated from serum induce apoptosis on EBV-specific CD8(+) Fas(+) cytotoxic T lymphocytes (CTL). CTL apoptosis is induced by thc binding of sHLA-I molecules to CD8 and its extent depends on the time of incubation with sHLA-I molecules. Apoptosis is triggered by the interaction of Fas(+) CTL with soluble Fas-ligand, which is released following che binding of sHLA-I antigens to CD8 molecules. These results suggest that sHLA-I molecules may regulate immune responses by inducing apoptosis in virus-specific CTL. (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.
引用
收藏
页码:1347 / 1351
页数:5
相关论文
共 34 条
  • [31] Role of Fas-mediated cell death in the regulation of immune responses
    vanParijs, L
    Abbas, AK
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (03) : 355 - 361
  • [32] ANTI HL-A2 INHIBITOR IN NORMAL HUMAN SERUM
    VANROOD, JJ
    VANLEEUW.A
    VANSANTE.MC
    [J]. NATURE, 1970, 226 (5243) : 366 - &
  • [33] INVOLVEMENT OF APOPTOSIS ANTIGEN FAS IN CLONAL DELETION OF HUMAN THYMOCYTES
    YONEHARA, S
    NISHIMURA, Y
    KISHIL, S
    YONEHARA, M
    TAKAZAWA, K
    TAMATANI, T
    ISHII, A
    [J]. INTERNATIONAL IMMUNOLOGY, 1994, 6 (12) : 1849 - 1856
  • [34] Soluble HLA class I molecules induce apoptosis in alloreactive cytotoxic T lymphocytes
    Zavazava, N
    Kronke, M
    [J]. NATURE MEDICINE, 1996, 2 (09) : 1005 - 1010