Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene

被引：9

作者：

Alesso, SM

Yu, ZR

Pears, D

Worthington, PA

Luke, RWA

Bradley, M ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Avecia, Manchester M9 8ZS, Lancs, England

[3] Jealotts Hill Res Stn, Bracknell RG42 6EY, Berks, England

[4] AstraZeneca Pharmaceut, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON | 2003年 / 59卷 / 36期

关键词：

styrenic methoxypoly(ethylene glycol) (MPEG); monomer; resins; solid supports; solid phase synthesis;

D O I：

10.1016/S0040-4020(03)01100-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7163 / 7169

页数：7

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