Genomic strategies for personalized cancer therapy

被引：37

作者：

Garman, Katherine S. ^{[1
]}

Nevins, Joseph R. ^{[1
]}

Potti, Anil ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Duke Inst Genome Sci & Policy, Durham, NC 27710 USA

来源：

HUMAN MOLECULAR GENETICS | 2007年 / 16卷

关键词：

D O I：

10.1093/hmg/ddm184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Numerous recent studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in cancer and other complex diseases. These studies highlight the opportunity for strategies to achieve truly personalized cancer treatment. In particular, the ability to develop gene expression signatures will likely allow us to guide the use of currently available cancer drugs, develop new targeted therapeutics, and provide an opportunity to better match the most effective drug or drugs with the molecular characteristics of the individual patient.

引用

页码：R226 / R232

页数：7

共 36 条

[11] Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
Druker, Brian J.
Guilhot, Francois
O'Brien, Stephen G.
Gathmann, Insa
Kantarjian, Hagop
Gattermann, Norbert
Deininger, Michael W. N.
Silver, Richard T.
Goldman, John M.
Stone, Richard M.
Cervantes, Francisco
Hochhaus, Andreas
Powell, Bayard L.
Gabrilove, Janice L.
Rousselot, Philippe
Reiffers, Josy
Cornelissen, Jan J.
Hughes, Timothy
Agis, Hermine
Fischer, Thomas
Verhoef, Gregor
Shepherd, John
Saglio, Giuseppe
Gratwohl, Alois
Nielsen, Johan L.
Radich, Jerald P.
Simonsson, Bengt
Taylor, Kerry
Baccarani, Michele
So, Charlene
Letvak, Laurie
Larson, Richard A.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) : 2408 - 2417
[12] ETTINGER DS, 2006, J NATL COMPR CANC NA, V6, P548
[13] Converting a breast cancer microarray signature into a high-throughput diagnostic test
Glas, Annuska M.
Floore, Arno
Delahaye, Leonie J. M. J.
Witteveen, Anke T.
Pover, Rob C. F.
Bakx, Niels
Lahti-Domenici, Jaana S. T.
Bruinsma, Tako J.
Warmoes, Marc O.
Bernards, Rene
Wessels, Lodewyk F. A.
Van 't Veer, Laura J.
[J]. BMC GENOMICS, 2006, 7 (1)
[14] Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
Golub, TR
Slonim, DK
Tamayo, P
Huard, C
Gaasenbeek, M
Mesirov, JP
Coller, H
Loh, ML
Downing, JR
Caligiuri, MA
Bloomfield, CD
Lander, ES
[J]. SCIENCE, 1999, 286 (5439) : 531 - 537
[15] Predictors of overall and cancer-free survival of patients with localized prostate cancer treated with primary androgen suppression therapy: Results from the prostate cancer outcomes study
Graff, Julie N.
Mori, Motomi
Li, Hong
Garzotto, Mark
Penson, David
Potosky, Arnold L.
Beer, Tomasz M.
[J]. JOURNAL OF UROLOGY, 2007, 177 (04) : 1307 - 1312
[16] GREENE EL, 2002, AJCC CANC STAGING MA
[17] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations
Györffy, B
Surowiak, P
Kiesslich, O
Denkert, C
Schäfer, R
Dietel, M
Lage, H
[J]. INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (07) : 1699 - 1712
[18] Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer
Hess, Kenneth R.
Anderson, Keith
Symmans, W. Fraser
Valero, Vicente
Ibrahim, Nuhad
Mejia, Jaime A.
Booser, Daniel
Theriault, Richard L.
Buzdar, Aman U.
Dempsey, Peter J.
Rouzier, Roman
Sneige, Nour
Ross, Jeffrey S.
Vidaurre, Tatiana
Gomez, Henry L.
Hortobagyi, Gabriel N.
Pusztai, Lajos
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (26) : 4236 - 4244
[19] Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment
Holleman, A
Cheok, MH
den Boer, ML
Yang, WJ
Veerman, AJP
Kazemier, KM
Pei, DQ
Cheng, C
Pui, CH
Relling, MV
Janka-Schaub, GE
Pieters, R
Evans, WE
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (06) : 533 - 542
[20] Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: Rationale for patient selection
Huang, Fei
Reeves, Karen
Han, Xia
Fairchild, Craig
Platero, Suso
Wong, Tai W.
Lee, Francis
Shaw, Peter
Clark, Edwin
[J]. CANCER RESEARCH, 2007, 67 (05) : 2226 - 2238

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