Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative

被引:44
作者
Pan, J. [1 ]
Stehling, C. [1 ,2 ]
Muller-Hocker, C. [1 ,3 ]
Schwaiger, B. J. [1 ,4 ]
Lynch, J. [5 ]
McCulloch, C. E. [5 ]
Nevitt, M. C. [5 ]
Link, T. M. [1 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
[2] Univ Munster, Dept Clin Radiol, Munster, Germany
[3] Tech Univ Munich, Sch Med, D-8000 Munich, Germany
[4] Univ Munich, Sch Med, Munich, Germany
[5] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
Osteoarthritis; OAI; Cartilage; 12; WORMS; Vastus lateralis; Vastus medialis; PATELLOFEMORAL PAIN SYNDROME; BODY-SURFACE AREA; PHYSICAL-ACTIVITY; QUADRICEPS STRENGTH; ADDUCTION MOMENT; DISEASE SEVERITY; MUSCLE STRENGTH; RELAXATION-TIME; FOLLOW-UP; WOMEN;
D O I
10.1016/j.joca.2010.10.023
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
Objective: To study the role of vastus lateralis/vastus medialis cross-sectional area CSA ratio (VL/VM CSA ratio) in preclinical knee osteoarthritis (OA) using magnetic resonance imaging (MRI)-based cartilage 12 mapping technique and morphological analysis at 3.0T in non-symptomatic, middle-aged subjects. Material and methods: 174 non-symptomatic individuals aged 45-55 years with OA risk factors were selected from the Osteoarthritis Initiative (OAI) incidence cohort. OA-related knee abnormalities were analyzed using the whole-organ magnetic resonance imaging score (WORMS). Knee cartilage T2 maps were generated using sagittal 2D multi-echo spin-echo images of the right knee. CSA of thigh muscles was measured using axial T1W images of the right mid thigh. Spline-based segmentation of cartilage and muscles was performed on a SUN/SPARC workstation. Muscle measurements were normalized to body size using body surface area (BSA). Statistical significance was determined using Student's t-test, Pearson correlation test, and multiple regression models. To correct for multiple testing, Bonferroni adjustments were applied across all tests within each of the primary results tables (Tables III-VII). Results: Higher 12 values were associated with increased prevalence and severity of cartilage degeneration. In our study, male and female subjects with higher VL/VM CSA ratio demonstrated significantly lower mean cartilage 12 values (all compartments combined) (mean 44.10 vs 45.17, P = 0.0017), and significantly lower WORMS scores (mean 14.12 vs 18.68, P= 0.0316). Regression analyses of combined mean cartilage 12 using VL/VM CSA ratio as a continuous predictor showed a significant curvilinear relationship between these two variables (P = 0.0082). Conclusion: Our results suggested that higher VL/VM CSA ratio is associated with lower T2 values and decreased presence and severity of OA-related morphological changes. Additional studies will be needed to determine causality. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:65 / 73
页数:9
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