Significance of CD90+ cancer stem cells in human liver cancer

被引：1150

作者：

Yang, Zhen Fan ^{[1
,2
]}

Ho, David W. ^{[1
,2
]}

Ng, Michael N. ^{[1
,2
]}

Lau, Chi Keung ^{[1
,2
]}

Yu, Wan Ching ^{[1
,2
]}

Ngai, Patricia ^{[1
,2
]}

Chu, Patrick W. K. ^{[1
,2
]}

Lam, Chi Tat ^{[1
,2
]}

Poon, Ronnie T. P. ^{[1
,2
]}

Fan, Sheung Tat ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Canc Res Ctr, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China

来源：

CANCER CELL | 2008年 / 13卷 / 02期

关键词：

D O I：

10.1016/j.ccr.2008.01.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90(+) cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45(-)CD90(+) population, which could generate tumor nodules in immunodeficient mice. The CD90(+)CD44(+) cells demonstrated a more aggressive phenotype than the CD90(+)CD44(-) counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90(+) cells. Differential gene expression profiles were identified in the CD45(-)CD90(+) and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls.

引用

页码：153 / 166

页数：14

共 54 条

[51] Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway [J].