The splice of life: Alternative splicing and neurological disease

被引:128
作者
Dredge, BK [1 ]
Polydorides, AD [1 ]
Darnell, RB [1 ]
机构
[1] Rockefeller Univ, Mol Neurooncol Lab, New York, NY 10021 USA
关键词
D O I
10.1038/35049061
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases. Neuron-specific proteins involved in RNA splicing and metabolism are also affected in several neurological disorders. These findings have begun to bridge what we know about the mechanisms regulating neuron-specific splicing and our understanding of neural function and disease.
引用
收藏
页码:43 / 50
页数:8
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