The mediator of RNA polymerase II

被引:84
作者
Blazek, E
Mittler, G
Meisterernst, M
机构
[1] Natl Res Ctr Environm & Hlth GSF, Inst Mol Immunol, D-81377 Munich, Germany
[2] Univ So Denmark, CEBI, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark
关键词
D O I
10.1007/s00412-005-0329-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mediator (TRAP/ARC/PC2) is a large (22-28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of transcription. During evolution the complex has acquired additional species-specific subunits. These serve as an interface for regulatory factors and support specific signalling pathways. Recent mechanistic studies are consistent with the hypothesis that Mediator marks genes for binding by RNA polymerase II whereupon it subsequently activates the preinitiation complex. It is further likely that Mediator coordinates the recruitment of chromatin-modifying cofactor activities.
引用
收藏
页码:399 / 408
页数:10
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