Delivering the message: epimorphin and mammary epithelial morphogenesis

被引：55

作者：

Radisky, DC

Hirai, Y

Bissell, MJ ^{[1
]}

机构：

[1] Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Sumitomo Elect Ind Ltd, Osaka R&D Lab, Yokohama Lab, Yokohama, Kanagawa, Japan

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(03)00146-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammary gland consists of a highly branched tubular epithelium surrounded by a complex mesenchymal stroma. Epimorphin is an extracellular protein that is expressed by mammary mesenchymal cells that directs epithelial morphogenesis. Depending upon the context of presentation - polar versus apolar - epimorphin can selectively direct two key processes of tubulogenesis: branching morphogenesis (processes involved in tubule initiation and extension) and luminal morphogenesis (required for enlargement of tubule caliber). Here, we outline the fundamentals of mammary gland development and describe the function of epimorphin in these processes. We conclude with a review of recent studies that suggest similar morphogenic roles for epimorphin in other glandular organs.

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收藏

页码：426 / 434

页数：9

相关论文

共 119 条

[1] Tube or not tube: Remodeling epithelial tissues by branching morphogenesis [J].

Affolter, M ;

Bellusci, S ;

Itoh, N ;

Shilo, B ;

Thiery, JP ;

Werb, Z .

DEVELOPMENTAL CELL, 2003, 4 (01) :11-18

[2] Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin [J].

Akimov, SS ;

Krylov, D ;

Fleischman, LF ;

Belkin, AM .

JOURNAL OF CELL BIOLOGY, 2000, 148 (04) :825-838

[3]

Akiyama M, 1999, BRIT J DERMATOL, V141, P447

[4] Extracellular export of sphingosine kinase-1 enzyme - Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation [J].

Ancellin, N ;

Colmont, C ;

Su, J ;

Li, Q ;

Mittereder, N ;

Chae, SS ;

Stefansson, S ;

Liau, G ;

Hla, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (08) :6667-6675

[5] The secretory route of the leaderless protein interleukin 1β involves exocytosis of endolysosome-related vesicles [J].

Andrei, C ;

Dazzi, C ;

Lotti, L ;

Torrisi, MR ;

Chimini, G ;

Rubartelli, A .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (05) :1463-1475

[6] Physiological functions of thioredoxin and thioredoxin reductase [J].

Arnér, ESJ ;

Holmgren, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (20) :6102-6109

[7]

Assmann V, 1999, J CELL SCI, V112, P3943

[8] THE SYNTAXIN FAMILY OF VESICULAR TRANSPORT RECEPTORS [J].

BENNETT, MK ;

GARCIAARRARAS, JE ;

ELFERINK, LA ;

PETERSON, K ;

FLEMING, AM ;

HAZUKA, CD ;

SCHELLER, RH .

CELL, 1993, 74 (05) :863-873

[9] Thioredoxin, a redox enzyme released in infection and inflammation, is a unique chemoattractant for neutrophils, monocytes, and T cells [J].

Bertini, R ;

Howard, OMZ ;

Dong, HF ;

Oppenheim, JJ ;

Bizzarri, C ;

Sergi, R ;

Caselli, G ;

Pagliei, S ;

Romines, B ;

Wilshire, JA ;

Mengozzi, M ;

Nakamura, H ;

Yodoi, J ;

Pekkari, K ;

Gurunath, R ;

Holmgren, A ;

Herzenberg, LA ;

Herzenberg, LA ;

Ghezzi, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) :1783-1789

[10] Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase [J].

Birchmeier, C ;

Gherardi, E .

TRENDS IN CELL BIOLOGY, 1998, 8 (10) :404-410

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