Clinicopathologic correlation of fluorescein and indocyanine green angiography in exudative age-related macular degeneration

被引:13
作者
Lauer, AK
Wilson, DJ
Klein, ML
机构
[1] Oregon Hlth Sci Univ, Casey Eye Inst, Leonard Christensen Eye Pathol Lab, Portland, OR 97201 USA
[2] Oregon Hlth Sci Univ, Macular Degenerat Ctr, Portland, OR 97201 USA
来源
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2000年 / 20卷 / 05期
关键词
age-related macular degeneration; choroidal neovascularization; clinicopathologic correlation; fluorescein angiography; indocyanine green angiography; retinal cartography; retinal mapping;
D O I
10.1097/00006982-200009000-00010
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To correlate the clinical and histopathologic features of an eye with age-related macular degeneration studied with fluorescein (FA) and indocyanine green (ICG) angiography 4.5 months before the patient's death. Methods: Histopathologic features from serial sections through the macula of a 76-year-old man with occult choroidal neovascularization (CNV) were reconstructed in a scaled two-dimensional map and compared with FA and ICG angiogram images obtained 4.5 months before his death. Results: The region of prior laser photocoagulation was identified as a well-demarcated hypofluorescent region in the early frames of the FA and the early and late phases of the ICG angiogram. This corresponded histopathologically to a well-circumscribed area of absence of the choriocapillaris, loss of the outer retina and retinal pigment epithelium, and scarring of the choroid, Occult CNV characterized by elevated late hyperfluorescence on the FA and intense well-defined hyperfluorescence on the ICG angiogram corresponded to a thick fibrovascular membrane in the subretinal space and within Bruch's membrane, Thin extensions of both the subretinal and intra-Bruch's membrane fibrovascular membrane components corresponded to nonelevated stippled late hyperfluorescence on the FA and mild late hyperfluorescence on the ICG angiogram. Conclusion: Histopathologic mapping revealed a large fibrovascular complex located subretinally and within Bruch's membrane with thin and thick components that correlate well with findings of occult CNV on FA and ICG angiography.
引用
收藏
页码:492 / 499
页数:8
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