3D shaped mechanically flexible diamond microelectrode arrays for eye implant applications: The MEDINAS project

被引:46
作者
Bergonzo, P. [1 ]
Bongrain, A. [1 ,2 ]
Scorsone, E. [1 ]
Bendali, A. [3 ,4 ]
Rousseau, L. [2 ]
Lissorgues, G. [2 ]
Mailley, P. [9 ]
Li, Y. [5 ,6 ]
Kauffmann, T. [7 ]
Goy, F. [7 ]
Yvert, B. [5 ,6 ]
Sahel, J. A. [3 ,4 ,8 ]
Picaud, S. [3 ,4 ,8 ]
机构
[1] CEA Saclay, Diamond Sensor Lab, LIST, CEA, F-91191 Gif Sur Yvette, France
[2] Univ Paris Est, ESIEE ESYCOM, F-93162 Noisy Le Grand, France
[3] Inst Vis, INSERM, U968, F-75012 Paris, France
[4] Univ Paris 06, UMR S968, Inst Vis, F-75012 Paris, France
[5] Univ Bordeaux, INCIA, UMR 5287, F-33000 Bordeaux, France
[6] CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France
[7] Biolog SAS, F-38640 Claix, France
[8] Fdn Ophtalmol Adolphe Rothschild, Paris, France
[9] CEA, CNRS, UJF, INAC,SPrAM,UMR 5819, F-38054 Grenoble, France
关键词
Neurobiological interfaces; CVD diamond; Retina implant; Micro-Electrode Arrays; BRAIN-STIMULATION; PROSTHESIS; RETINA; CELLS;
D O I
10.1016/j.irbm.2011.01.032
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The MEDINAS project aims at the fabrication of Micro-Electrode Arrays (MEA) that take advantage of a novel electrode material, namely synthetic conducting diamond, as the bio-interface material. Diamond enables the fabrication of electrodes with high biocompatibility, high electrochemical interfacing performances and long-term stability. The project aims at the development of diamond based MEAs for recording and stimulating of neuron networks for both in vitro applications (rigid substrate) as well as for in vivo retinal prostheses (flexible biocompatible substrate). The performances of this new technology were assessed as compared to standard metallic solutions. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:91 / 94
页数:4
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