The relationship between amyloid and tau

被引：66

作者：

Hardy, J ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2003年 / 20卷 / 02期

关键词：

amyloid; plaques; tangles; tau; genetic; Alzheimer's disease; Pick's disease;

D O I：

10.1385/JMN:20:2:203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

引用

页码：203 / 206

页数：4

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