The relationship between amyloid and tau

被引：66

作者：

Hardy, J ^{[1
]}

机构：

[1] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2003年 / 20卷 / 02期

关键词：

amyloid; plaques; tangles; tau; genetic; Alzheimer's disease; Pick's disease;

D O I：

10.1385/JMN:20:2:203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on genetic findings, the relationship between the APP/Abeta and tau/tangle pathologies are discussed. It is argued that APP/Abeta is upstream of tau/tangle in the Alzheimer pathogenesis, and that the relationship between the pathologies are promiscuous in two ways: first, APP/Abeta can equally be seen to be upstream of synuclein/Lewy bodies in cell death pathways, and second, tau pathology can be initiated by genetic lesions in other pathways.

引用

页码：203 / 206

页数：4

共 18 条

[11] Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice [J].

Leissring, MA ;

Akbari, Y ;

Fanger, CM ;

Cahalan, MD ;

Mattson, MP ;

LaFerla, FM .

JOURNAL OF CELL BIOLOGY, 2000, 149 (04) :793-797

[12] CANDIDATE GENE FOR THE CHROMOSOME-1 FAMILIAL ALZHEIMERS-DISEASE LOCUS [J].

LEVYLAHAD, E ;

WASCO, W ;

POORKAJ, P ;

ROMANO, DM ;

OSHIMA, J ;

PETTINGELL, WH ;

YU, CE ;

JONDRO, PD ;

SCHMIDT, SD ;

WANG, K ;

CROWLEY, AC ;

FU, YH ;

GUENETTE, SY ;

GALAS, D ;

NEMENS, E ;

WIJSMAN, EM ;

BIRD, TD ;

SCHELLENBERG, GD ;

TANZI, RE .

SCIENCE, 1995, 269 (5226) :973-977

[13] Lewy bodies contain altered α-synuclein in brains of many familiar Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes [J].

Lippa, CF ;

Fujiwara, H ;

Mann, DMA ;

Giasson, B ;

Baba, M ;

Schmidt, ML ;

Nee, LE ;

O'Connell, B ;

Pollen, DA ;

George-Hyslop, PS ;

Ghetti, B ;

Nochlin, D ;

Bird, TD ;

Cairns, NJ ;

Lee, VMY ;

Iwatsubo, T ;

Trojanowski, JQ .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (05) :1365-1370

[14] Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q [J].

Mori, H ;

Kondo, T ;

Yokochi, M ;

Matsumine, H ;

Nakagawa-Hattori, Y ;

Miyake, T ;

Suda, K ;

Mizuno, Y .

NEUROLOGY, 1998, 51 (03) :890-892

[15] Susceptibility locus for Alzheimer's disease on chromosome 10 [J].

Myers, A ;

Holmans, P ;

Marshall, H ;

Kwon, J ;

Meyer, D ;

Ramic, D ;

Shears, S ;

Booth, J ;

DeVrieze, FW ;

Crook, R ;

Hamshere, M ;

Abraham, R ;

Tunstall, N ;

Rice, F ;

Carty, S ;

Lillystone, S ;

Kehoe, P ;

Rudrasingham, V ;

Jones, L ;

Lovestone, S ;

Perez-Tur, J ;

Williams, J ;

Owen, MJ ;

Hardy, J ;

Goate, AM .

SCIENCE, 2000, 290 (5500) :2304-+

[16] CLONING OF A GENE BEARING MISSENSE MUTATIONS IN EARLY-ONSET FAMILIAL ALZHEIMERS-DISEASE [J].

SHERRINGTON, R ;

ROGAEV, EI ;

LIANG, Y ;

ROGAEVA, EA ;

LEVESQUE, G ;

IKEDA, M ;

CHI, H ;

LIN, C ;

LI, G ;

HOLMAN, K ;

TSUDA, T ;

MAR, L ;

FONCIN, JF ;

BRUNI, AC ;

MONTESI, MP ;

SORBI, S ;

RAINERO, I ;

PINESSI, L ;

NEE, L ;

CHUMAKOV, I ;

POLLEN, D ;

BROOKES, A ;

SANSEAU, P ;

POLINSKY, RJ ;

WASCO, W ;

DASILVA, HAR ;

HAINES, JL ;

PERICAKVANCE, MA ;

TANZI, RE ;

ROSES, AD ;

FRASER, PE ;

ROMMENS, JM ;

STGEORGEHYSLOP, PH .

NATURE, 1995, 375 (6534) :754-760

[17]

Vidal R, 1999, NATURE, V399, P776

[18] Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease [J].

Wavrant-De Vrièze, F ;

Crook, R ;

Holmans, P ;

Kehoe, P ;

Owen, MJ ;

Williams, J ;

Roehl, K ;

Laliiri, DK ;

Shears, S ;

Booth, J ;

Wu, W ;

Goate, A ;

Chartier-Harlin, MC ;

Hardy, J ;

Pérez-Tur, J .

NEUROSCIENCE LETTERS, 1999, 269 (02) :67-70

← 1 2 →