A review of the safety of 50% nitrous oxide/oxygen in conscious sedation

被引:33
作者
Collado, Valerie
Nicolas, Emmanuel
Faulks, Denise
Hennequin, Martine
机构
[1] Univ Clermont Ferrand 1, Fac Odontol, CHU Clermont Ferrand, EA 3847, Clermont Ferrand, France
[2] CHU Clermont Ferrand, Serv Odontol, Hotel Dieu, F-63000 Clermont Ferrand, France
关键词
adverse events; nitrous oxide; safety; sedation;
D O I
10.1517/14740338.6.5.559
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
Few studies into conscious sedation with 50% nitrous oxide/oxygen premix (50% N2O/O-2) have been conducted in accordance with Good Clinical Practice in Clinical Trials. Of the 140 articles retained in this review, the incidence of adverse events (AEs) varied in the range of 0-68% according to the indications. When other drugs and/or local anaesthesia were used concomitantly, the relative risk for nausea and vomiting increased whereas it decreased for vertigo or hallucinations. Only one study examined potential causal relationship between serious AEs and the 50% N2O/O-2 gas itself, giving a risk for a serious AE directly due to the gas of 3/10,000 administrations. No analysis of the effect of the method of administration was possible, nor could conclusions be drawn relating to the risk of occupational exposure.
引用
收藏
页码:559 / 571
页数:13
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