GDF11 and the Mythical Fountain of Youth

被引：49

作者：

Brun, Caroline E. ^{[1
,2
]}

Rudnicki, Michael A. ^{[1
,2
]}

机构：

[1] Ottawa Hosp Res Inst, Regenerat Med Program, Sprott Ctr Stem Cell Res, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Cellular & Mol Med, Fac Med, Ottawa, ON K1H 8L6, Canada

来源：

CELL METABOLISM | 2015年 / 22卷 / 01期

关键词：

SKELETAL-MUSCLE; DIFFERENTIATION; REJUVENATION; HYPERTROPHY; MASS;

D O I：

10.1016/j.cmet.2015.05.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Identifying candidates that rejuvenate aged muscle stem cells is an important strategy toward developing therapies to treat age-related diseases. In this issue, Egerman et al. (2015) re-investigate the activity of GDF11 in myogenesis, recently suggested as an anti-aging agent, and instead find a potent inhibitory effect on skeletal muscle regeneration.

引用

页码：54 / 56

页数：3

共 11 条

[1]

Rejuvenation of aged progenitor cells by exposure to a young systemic environment [J].

Conboy, IM ;

Conboy, MJ ;

Wagers, AJ ;

Girma, ER ;

Weissman, IL ;

Rando, TA .

NATURE, 2005, 433 (7027) :760-764

[2]

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration [J].

Egerman, Marc A. ;

Cadena, Samuel M. ;

Gilbert, Jason A. ;

Meyer, Angelika ;

Nelson, Hallie N. ;

Swalley, Susanne E. ;

Mallozzi, Carolyn ;

Jacobi, Carsten ;

Jennings, Lori L. ;

Clay, Ieuan ;

Laurent, Gaelle ;

Ma, Shenglin ;

Brachat, Sophie ;

Lach-Trifilieff, Estelle ;

Shavlakadze, Tea ;

Trendelenburg, Anne-Ulrike ;

Brack, Andrew S. ;

Glass, David J. .

CELL METABOLISM, 2015, 22 (01) :164-174

[3]

Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb [J].

Gamer, LW ;

Cox, KA ;

Small, C ;

Rosen, V .

DEVELOPMENTAL BIOLOGY, 2001, 229 (02) :407-420

[4]

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors [J].

Katsimpardi, Lida ;

Litterman, Nadia K. ;

Schein, Pamela A. ;

Miller, Christine M. ;

Loffredo, Francesco S. ;

Wojtkiewicz, Gregory R. ;

Chen, John W. ;

Lee, Richard T. ;

Wagers, Amy J. ;

Rubin, Lee L. .

SCIENCE, 2014, 344 (6184) :630-634

[5]

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy [J].

Lach-Trifilieff, Estelle ;

Minetti, Giulia C. ;

Sheppard, KellyAnn ;

Ibebunjo, Chikwendu ;

Feige, Jerome N. ;

Hartmann, Steffen ;

Brachat, Sophie ;

Rivet, Helene ;

Koelbing, Claudia ;

Morvan, Frederic ;

Hatakeyama, Shinji ;

Glass, David J. .

MOLECULAR AND CELLULAR BIOLOGY, 2014, 34 (04) :606-618

[6]

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2 [J].

Lee, Yun-Sil ;

Lee, Se-Jin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (39) :E3713-E3722

[7]

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy [J].

Loffredo, Francesco S. ;

Steinhauser, Matthew L. ;

Jay, Steven M. ;

Gannon, Joseph ;

Pancoast, James R. ;

Yalamanchi, Pratyusha ;

Sinha, Manisha ;

Dall'Osso, Claudia ;

Khong, Danika ;

Shadrach, Jennifer L. ;

Miller, Christine M. ;

Singer, Britta S. ;

Stewart, Alex ;

Psychogios, Nikolaos ;

Gerszten, Robert E. ;

Hartigan, Adam J. ;

Kim, Mi-Jeong ;

Serwold, Thomas ;

Wagers, Amy J. ;

Lee, Richard T. .

CELL, 2013, 153 (04) :828-839

[8]

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member [J].

McPherron, AC ;

Lawler, AM ;

Lee, SJ .

NATURE, 1997, 387 (6628) :83-90

[9]

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle [J].

Sinha, Manisha ;

Jang, Young C. ;

Oh, Juhyun ;

Khong, Danika ;

Wu, Elizabeth Y. ;

Manohar, Rohan ;

Miller, Christine ;

Regalado, Samuel G. ;

Loffredo, Francesco S. ;

Pancoast, James R. ;

Hirshman, Michael F. ;

Lebowitz, Jessica ;

Shadrach, Jennifer L. ;

Cerletti, Massimiliano ;

Kim, Mi-Jeong ;

Serwold, Thomas ;

Goodyear, Laurie J. ;

Rosner, Bernard ;

Lee, Richard T. ;

Wagers, Amy J. .

SCIENCE, 2014, 344 (6184) :649-652

[10]

Proteomic Identification and Functional Validation of Activins and Bone Morphogenetic Protein 11 as Candidate Novel Muscle Mass Regulators [J].

Souza, Tatyana A. ;

Chen, Xuan ;

Guo, Yongjing ;

Sava, Parid ;

Zhang, Jimin ;

Hill, Jennifer J. ;

Yaworsky, Paul J. ;

Qiu, Yongchang .

MOLECULAR ENDOCRINOLOGY, 2008, 22 (12) :2689-2702

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