Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

被引：879

作者：

Katsimpardi, Lida ^{[1
,2
]}

Litterman, Nadia K. ^{[1
,2
]}

Schein, Pamela A. ^{[1
,2
]}

Miller, Christine M. ^{[1
,2
,3
,4
]}

Loffredo, Francesco S. ^{[1
,2
,5
]}

Wojtkiewicz, Gregory R. ^{[6
,7
]}

Chen, John W. ^{[6
,7
]}

Lee, Richard T. ^{[1
,2
,5
]}

Wagers, Amy J. ^{[1
,2
,3
,4
]}

Rubin, Lee L. ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[2] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Med, Howard Hughes Med Inst, Joslin Diabet Ctr, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Paul F Glenn Labs Biol Mech Aging, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Ctr Syst Biol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA

来源：

SCIENCE | 2014年 / 344卷 / 6184期

关键词：

CENTRAL-NERVOUS-SYSTEM; NEURAL STEM-CELLS; SUBVENTRICULAR ZONE; DENTATE GYRUS; ADULT; PROLIFERATION; DIFFERENTIATION; EXPRESSION; HIPPOCAMPUS; MICE;

D O I：

10.1126/science.1251141

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.

引用

页码：630 / 634

页数：5

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