Novel metabolites of warfarin produced by Beauveria bassiana and Streptomyces rimosus: A novel application of hplc-nmr

被引：20

作者：

Cannell, RJP ^{[1
]}

Rashid, T ^{[1
]}

Ismail, IM ^{[1
]}

Sidebottom, PJ ^{[1
]}

Knaggs, AR ^{[1
]}

Marshall, PS ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

XENOBIOTICA | 1997年 / 27卷 / 02期

关键词：

D O I：

10.1080/004982597240659

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Biotransformation of warfarin by the fungus Beauveria bassiana (ATCC 7159) yielded the first reported phase II warfarin metabolite, 3',4'-dihydroxywarfarin-3'-[4-methoxyglucoside], another previously unreported metabolite, 3', 4'-dihydroxywarfarin and also 4'-hydroxywarfarin. 2. Biotransformation of warfarin by Streptomyces rimosus (NRRL 2234) yielded the previously unreported metabolites, 12-hydroxywarfarin, 4'-hydroxy-11-methoxywarfarin, and also 7-hydroxywarfarin and 4'-hydroxywarfarin, which have not been previously reported as biotransformation products from this organism. 3. Hplc-nmr has been used to identify biotransformation products of warfarin by S. rimosus directly from the microbial broth without prior isolation and purification.

引用

页码：147 / 157

页数：11

共 20 条

[1] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].