Efficient large-scale synthesis of 2-amino-5-methanesulfonylaminobenzenesulfonamide

被引：2

作者：

Dragovich, Peter S. ^{[1
]}

Murphy, Douglas E. ^{[1
]}

Tran, Chinh V. ^{[1
]}

Ruebsam, Frank ^{[1
]}

机构：

[1] Anadys Pharmaceut, San Diego, CA USA

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 12期

关键词：

2-amino-5-methanesulfonylaminobenzenesulfonamide; Friedel-Crafts acylation; sulfonamide;

D O I：

10.1080/00397910801997512

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthesis of 2-amino-5-methanesulfonylaminobenzenesulfonamide is described. This preparation begins with readily available 4-nitroaniline and proceeds through five steps (isolations) in 41% overall yield. The described chemistry is conducted on a 50- to 100-g scale and does not require extractive workup procedures or chromatographic purifications.

引用

页码：1909 / 1916

页数：8

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