General ageing and ovarian ageing

被引：47

作者：

Dorland, M ^{[1
]}

van Kooij, RJ ^{[1
]}

Velde, ERT ^{[1
]}

机构：

[1] Univ Utrecht Hosp, Div Obstet & Gynaecol, Dept Reprod Med, NL-3584 CX Utrecht, Netherlands

来源：

MATURITAS | 1998年 / 30卷 / 02期

关键词：

aging; fertility; ovarian aging; oocyte;

D O I：

10.1016/S0378-5122(98)00066-8

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The age related decrease in female fertility is associated with a decrease in follicle numbers and oocyte quality. Meiotic division errors, mitochondrial DNA mutations and ageing itself have been suggested to play a part in the age associated reduction in oocyte quality. During the past decades several hypothesis have been proposed, trying to explain the underlying mechanisms. However, none of them is yet conclusive. This review will consider the main hypotheses regarding the age related reduction in oocyte quality. This will be reviewed together with recent results of studies analysing a possible relationship between ageing and ovarian ageing. On the basis of our own results and those presented in the literature, it is concluded that ovarian ageing may only be related to specific aspects of general ageing. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：113 / 118

页数：6

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