In-vivo evaluation of chronically implanted neural microelectrode arrays modified with poly (3,4-ethylenedioxythiophene) nanotubes

被引：16

作者：

Abidian, Mohammad Reza ^{[1
]}

Salas, Luis G. ^{[1
]}

Yazdan-Shahmorad, Azadeh ^{[1
]}

Marzullo, Timothy C. ^{[2
]}

Martin, David C. ^{[3
]}

Kipke, Daryl R. ^{[1
]}

机构：

[1] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Program Neurosci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biomed Engn, Mat Sci & Engn, Macromol Sci & Engn, Ann Arbor, MI 48109 USA

来源：

2007 3RD INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, VOLS 1 AND 2 | 2007年

关键词：

D O I：

10.1109/CNE.2007.369612

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The interface between neural prostheses and neural tissue plays a significant role in the long term performance of these devices. Conducting polymers have been used to modify the electrical properties of neural microelectrodes. The objective of this study was to evaluate recording chronic neural activity of neural microelectrodes that were modified with nanofibers-templated of poly (3,4-ethylenedioxythiophene) (PEDOT) nanotubes over seven week periods using impedance spectroscopy and signal-to-noise ratio measurements. PEDOT nanotubes-coated sites were found to have lower impedance and higher signal-to-noise ratio than control site.

引用

页码：61 / +

页数：2

共 21 条

[1] Conducting-polymer nanotubes for controlled drug release [J].

Abidian, MR ;

Kim, DH ;

Martin, DC .

ADVANCED MATERIALS, 2006, 18 (04) :405-+

[2] Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays [J].

Biran, R ;

Martin, DC ;

Tresco, PA .

EXPERIMENTAL NEUROLOGY, 2005, 195 (01) :115-126

[3]

Black J, 1999, BIOL PERFORMANCE MAT

[4] Electrochemical deposition and characterization of conducting polymer polypyrrole/PSS on multichannel neural probes [J].

Cui, XY ;

Hetke, JF ;

Wiler, JA ;

Anderson, DJ ;

Martin, DC .

SENSORS AND ACTUATORS A-PHYSICAL, 2001, 93 (01) :8-18

[5] FACTORS INFLUENCING THE BIOCOMPATIBILITY OF INSERTABLE SILICON MICROSHAFTS IN CEREBRAL-CORTEX [J].

EDELL, DJ ;

TOI, VV ;

MCNEIL, VM ;

CLARK, LD .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1992, 39 (06) :635-643

[6] STIMULATION OF MONOLAYER NETWORKS IN CULTURE THROUGH THIN-FILM INDIUM-TIN OXIDE RECORDING ELECTRODES [J].

GROSS, GW ;

RHOADES, BK ;

REUST, DL ;

SCHWALM, FU .

JOURNAL OF NEUROSCIENCE METHODS, 1993, 50 (02) :131-143

[7]

Jansen M, 2001, NOISE REDUCTION WAVE

[8] Restoration of neural output from a paralyzed patient by a direct brain connection [J].

Kennedy, PR ;

Bakay, RAE .

NEUROREPORT, 1998, 9 (08) :1707-1711

[9] Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices [J].

Kim, DH ;

Abidian, M ;

Martin, DC .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 71A (04) :577-585

[10]

Kovacs G.T. A., 1994, Enabling Technologies for Cultured Neural Networks, P121, DOI DOI 10.1016/j.jneumeth.2004.03.005

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